reviewTop 1% cited

Growing roles for the mTOR pathway

Current Opinion in Cell Biology · 2005 · Vol. 17(6) · pp. 596–603

Dos D. SarbassovSiraj M. Ali(Whitehead Institute for Biomedical Research)David M. Sabatini✉(Whitehead Institute for Biomedical Research)

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PI3K/AKT/mTOR signaling in cancer Polyamine Metabolism and Applications Metabolism, Diabetes, and CancerRHEBPI3K/AKT/mTOR pathwayBiologyAutophagyRibosome biogenesisRPTORTSC1RegulatormTORC2TSC2

MeSH terms

AnimalsDiseaseHumansModels, BiologicalNeoplasmsProtein KinasesSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Funding

National Institutes of Health

Citations

1,547

FWCI

29.39

field-weighted impact

References

Percentile

100%

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Citations per year

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References

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

Nature Cell Biology · 2001 · 1,559 citations

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

Molecular Endocrinology · 2000 · 412 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Rheb Binds and Regulates the mTOR Kinase

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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

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