review Open AccessTop 1% cited

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

Cell Death and Differentiation · 2008 · Vol. 16(1) · pp. 46–56

Sovan Sarkar✉(University of Cambridge)Brinda Ravikumar(University of Cambridge)R. Andrés Floto(Addenbrooke's Hospital)David C. Rubinsztein(University of Cambridge)

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Genetic Neurodegenerative Diseases Mitochondrial Function and Pathology Amyotrophic Lateral Sclerosis ResearchAutophagyHuntingtinPI3K/AKT/mTOR pathwayCell biologyBiologyHuntingtin ProteinMechanistic target of rapamycinTFEBNeurodegenerationProgrammed cell death

MeSH terms

Huntingtin ProteinAnimalsAntibiotics, AntineoplasticAutophagyDisease Models, AnimalDrosophilaGene Expression RegulationHumansMutationNerve Tissue ProteinsNuclear ProteinsPeptidesProtein KinasesProtein BiosynthesisSignal Transduction

Funding

Wellcome Trust
NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
National Institute for Health and Care Research
Medical Research Council

Citations

580

FWCI

11.65

field-weighted impact

References

Percentile

99%

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Citations per year

Cited by

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers