review Open AccessTop 1% cited

Defining the Role of mTOR in Cancer

Cancer Cell · 2007 · Vol. 12(1) · pp. 9–22

David A. Guertin(Whitehead Institute for Biomedical Research)David M. Sabatini✉(Massachusetts Institute of Technology)

PI3K/AKT/mTOR signaling in cancer Polyamine Metabolism and Applications Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR pathwayDiscovery and development of mTOR inhibitorsRPTOREffectormTORC2Mechanistic target of rapamycinCancerCancer researchSirolimusBiology

MeSH terms

Antineoplastic AgentsHumansNeoplasmsProtein KinasesSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Citations

2,803

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74.39

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144

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References

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular Cell · 2006 · 2,633 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Developmental Cell · 2006 · 1,398 citations

FOXO transcription factors at the interface between longevity and tumor suppression

Oncogene · 2005 · 1,297 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology · 2002 · 3,038 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Current Biology · 2004 · 2,646 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Nature Cell Biology · 2007 · 1,164 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Molecular Cell · 2002 · 1,548 citations

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