articleTop 1% cited
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Nature Cell Biology · 2001 · Vol. 3(11) · pp. 1014–1019
Sue C. Bodine✉(Regeneron (United States))Trevor N. Stitt(Regeneron (United States))Michael Gonzalez(Regeneron (United States))William O. Kline(Regeneron (United States))Gretchen L. Stover(Regeneron (United States))Roy Bauerlein(Regeneron (United States))Elizabeth Zlotchenko(Regeneron (United States))Angus G. Scrimgeour(University of Virginia)John C. Lawrence(University of Virginia)David J. Glass(Regeneron (United States))George D. Yancopoulos(Regeneron (United States))
Muscle Physiology and DisordersSignaling Pathways in DiseaseNeurogenetic and Muscular Disorders ResearchPI3K/AKT/mTOR pathwayMuscle hypertrophyProtein kinase BCalcineurinSkeletal muscleMuscle atrophyNFATInternal medicineRPTOREndocrinology
MeSH terms
AnimalsEnzyme InhibitorsFemaleCardiomegalyMuscular AtrophyProtein KinasesProto-Oncogene ProteinsSignal TransductionCyclosporineRats, Sprague-DawleyProtein Serine-Threonine KinasesMuscle, SkeletalCalcineurinRibosomal Protein S6 KinasesProto-Oncogene Proteins c-akt
Funding
- Regeneron Pharmaceuticals
Citations
2,692
FWCI
17.82
field-weighted impact
References
37
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100%
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References
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
Nature Cell Biology · 2001 · 1,559 citations
Phosphorylation of p70<sup>S6k</sup>correlates with increased skeletal muscle mass following resistance exercise
American Journal of Physiology-Cell Physiology · 1999 · 715 citations
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