articleTop 1% cited
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
Nature Cell Biology · 2001 · Vol. 3(11) · pp. 1009–1013
Christian Rommel✉(Regeneron (United States))Sue C. Bodine(Regeneron (United States))Brian Clarke(Regeneron (United States))Roni Rossman(Regeneron (United States))Lorna Nuñez(Regeneron (United States))Trevor N. Stitt(Regeneron (United States))George D. Yancopoulos(Regeneron (United States))David J. Glass(Regeneron (United States))
Muscle Physiology and DisordersSignaling Pathways in DiseaseNeurogenetic and Muscular Disorders ResearchProtein kinase BPI3K/AKT/mTOR pathwayMuscle hypertrophyCell biologyNFATCalcineurinGSK-3MyogenesisSignal transductionBiology
MeSH terms
Phosphoinositide-3 Kinase InhibitorsAnimalsCarrier ProteinsCell DifferentiationCell LineInsulin-Like Growth Factor IMuscular AtrophyPhosphoproteinsPhosphorylationProtein KinasesProto-Oncogene ProteinsSignal TransductionProtein Serine-Threonine KinasesCalcium-Calmodulin-Dependent Protein KinasesMuscle, Skeletal
Funding
- Regeneron Pharmaceuticals
Citations
1,559
FWCI
12.73
field-weighted impact
References
24
Percentile
99%
vs. same field & year
Citations per year
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References
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Nature Cell Biology · 2001 · 2,692 citations
Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*
Endocrine Reviews · 1996 · 1,089 citations
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