reviewTop 1% cited
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Nature Reviews Genetics · 2006 · Vol. 7(8) · pp. 606–619
Jeffrey A. Engelman✉(Harvard University)Ji Luo(Beth Israel Deaconess Medical Center)Lewis C. Cantley(Beth Israel Deaconess Medical Center)
PI3K/AKT/mTOR signaling in cancerCellular transport and secretionProtein Kinase Regulation and GTPase SignalingCrosstalkBiologyMulticellular organismKinaseCell biologyPhosphatidylinositolSignal transductionPI3K/AKT/mTOR pathwayFunction (biology)Genetics
MeSH terms
AnimalsCellsMultigene FamilyHumansEvolution, MolecularPhosphatidylinositol 3-KinasesCell Growth Processes
Citations
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References
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Nature Reviews Molecular Cell Biology · 2006 · 2,697 citations
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Nature Cell Biology · 2002 · 3,038 citations
Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas
International Journal of Cancer · 1995 · 836 citations
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Nature Genetics · 1997 · 2,757 citations
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Journal of Biological Chemistry · 1998 · 3,080 citations
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · 1,548 citations
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell · 1997 · 5,689 citations
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
Journal of Leukocyte Biology · 2003 · 450 citations
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