article Open AccessTop 10% cited
The natural history of epilepsy in tuberous sclerosis complex
Epilepsia · 2009 · Vol. 51(7) · pp. 1236–1241
Catherine J. Chu✉(Massachusetts General Hospital)Philippe Major(Massachusetts General Hospital)Susana Camposano(Massachusetts General Hospital)David A. Muzykewicz(Massachusetts General Hospital)Elizabeth A. Thiele(Massachusetts General Hospital)
Abstract
Most patients with TSC develop epilepsy and most develop multiple seizure types. Onset typically occurs in the first year of life; however, adults remain at risk. Although refractory epilepsy is common, many patients achieve seizure control. Many features of seizure history are predictive of cognitive and epilepsy outcome.
Tuberous Sclerosis Complex ResearchGenetic and Kidney Cyst DiseasesPolyomavirus and related diseasesEpilepsyTuberous sclerosisFamily historyPediatricsMedicineNatural historyAge of onsetEpilepsy syndromesGeneralized epilepsySeizure types
MeSH terms
AdolescentAdultChildChild, PreschoolEpilepsyFollow-Up StudiesHumansInfantInfant, NewbornMiddle AgedRetrospective StudiesTuberous SclerosisYoung Adult
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32
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98%
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References
Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs
The American Journal of Human Genetics · 2001 · 992 citations
Causes of Death in Patients With Tuberous Sclerosis
Mayo Clinic Proceedings · 1991 · 561 citations
Growing roles for the mTOR pathway
Current Opinion in Cell Biology · 2005 · 1,547 citations
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