article Open AccessTop 1% cited
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
Current Biology · 2003 · Vol. 13(15) · pp. 1259–1268
Andrew R. Tee✉(Harvard University)Brendan D. Manning(Beth Israel Deaconess Medical Center)Philippe P. Roux(Harvard University)Lewis C. Cantley(Beth Israel Deaconess Medical Center)John Blenis(Harvard University)
Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancerMast cells and histamineRHEBTSC1TSC2P70-S6 Kinase 1BiologyPI3K/AKT/mTOR pathwaySmall GTPaseRPTORCell biologyRibosomal protein s6
MeSH terms
Ras Homolog Enriched in Brain ProteinTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinBiological AssayCarrier ProteinsDNA-Binding ProteinsElectrophoresis, Polyacrylamide GelHumansNeuropeptidesPhosphoproteinsPlasmidsPrecipitin TestsProtein KinasesProteinsRepressor Proteins
Funding
- American Cancer Society
- European Molecular Biology Organization
- Human Frontier Science Program
- National Institutes of Health
Citations
1,203
FWCI
29.95
field-weighted impact
References
51
Percentile
100%
vs. same field & year
Citations per year
Cited by
mTOR: a pharmacologic target for autophagy regulation
Journal of Clinical Investigation · 2015 · 2,079 citations
mTOR signaling at a glance
Journal of Cell Science · 2009 · 2,135 citations
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
Biochemical Journal · 2008 · 1,234 citations
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Molecular Biology of the Cell · 2009 · 1,973 citations
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Biochemical Journal · 2011 · 1,004 citations
mTOR Signaling in Growth Control and Disease
Cell · 2012 · 8,373 citations
Rheb Binds and Regulates the mTOR Kinase
Current Biology · 2005 · 986 citations
Mitogenic signaling pathways induced by G protein‐coupled receptors
Journal of Cellular Physiology · 2007 · 454 citations
References
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · 1,548 citations
Regulation of translation initiation by FRAP/mTOR
Genes & Development · 2001 · 1,531 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.