article Open AccessTop 1% cited
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · Vol. 10(1) · pp. 151–162
Brendan D. Manning✉(Beth Israel Deaconess Medical Center)Andrew R. Tee(Harvard University)M. Nicole Logsdon(Beth Israel Deaconess Medical Center)John Blenis(Harvard University)Lewis C. Cantley(Beth Israel Deaconess Medical Center)
Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsPI3K/AKT/mTOR pathwayBiologyProtein kinase BPTENPhosphorylationKinaseP70-S6 Kinase 1Cell biologyTuberous sclerosisCancer research
MeSH terms
Tuberous Sclerosis Complex 2 ProteinAmino Acid SequenceAnimalsBinding SitesCell LineEnzyme ActivationHumansMolecular WeightMutationPhosphoric Monoester HydrolasesPhosphorylationProto-Oncogene ProteinsRepressor ProteinsSubstrate SpecificityTuberous Sclerosis
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References
Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs
The American Journal of Human Genetics · 2001 · 992 citations
Ten years of protein kinase B signalling: a hard Akt to follow
Trends in Biochemical Sciences · 2001 · 1,178 citations
The PI3K–PDK1 connection: more than just a road to PKB
Biochemical Journal · 2000 · 1,590 citations
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
Journal of Biological Chemistry · 1998 · 3,080 citations
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
Biochemical Journal · 1999 · 918 citations
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
Human Molecular Genetics · 2002 · 683 citations
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
Current Biology · 1997 · 2,824 citations
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