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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Nature Medicine · 2015 · Vol. 21(3) · pp. 248–255

Rebecca C. Coll✉(The University of Queensland)Avril A. B. Robertson(The University of Queensland)Jae Jin Chae(National Institutes of Health)Sarah Higgins(Trinity College Dublin)Raúl Muñoz-Planillo(University of Michigan)Marco Inserra(The University of Queensland)Irina Vetter(The University of Queensland)Lara S. Dungan(Trinity College Dublin)Brian G. Monks(University of Bonn)Andrea Stutz(University of Bonn)Daniel E. Croker(The University of Queensland)Mark S. Butler(The University of Queensland)Moritz Haneklaus(Trinity College Dublin)Caroline E. Sutton(Trinity College Dublin)Gabriel Núñez(University of Michigan)Eicke Latz(University of Bonn)Daniel L. Kastner(National Institutes of Health)Kingston H. G. Mills(Trinity College Dublin)Seth L. Masters(Walter and Eliza Hall Institute of Medical Research)Kate Schroder(The University of Queensland)Matthew A. Cooper(The University of Queensland)Luke O'neill(Trinity College Dublin)

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Inflammasome and immune disorders IL-33, ST2, and ILC Pathways Biomarkers in Disease MechanismsInflammasomePyrin domainExperimental autoimmune encephalomyelitisNALP3MedicineAIM2ImmunologyNodIn vivoNLRC4

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCarrier ProteinsDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFuransHeterocyclic Compounds, 4 or More RingsHumansIndenesInflammationMultiple SclerosisSulfonamidesSulfonesMiceInterleukin-1beta

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