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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Nature Immunology · 2010 · Vol. 11(10) · pp. 897–904

Seth L. Masters✉(Trinity College Dublin)Aisling Dunne(Trinity College Dublin)Shoba Subramanian(VA Puget Sound Health Care System)Rebecca L. Hull(VA Puget Sound Health Care System)Gillian M. Tannahill(Trinity College Dublin)Fiona A. Sharp(Trinity College Dublin)Christine Becker(Trinity College Dublin)Luigi Franchi(University of Michigan–Ann Arbor)Eiji Yoshihara(Kyoto University)Zhe Chen(Kyoto University)N Mullooly(University College Dublin)Lisa A. Mielke(Trinity College Dublin)James Harris(Trinity College Dublin)Rebecca C. Coll(Trinity College Dublin)Kingston H. G. Mills(Trinity College Dublin)K. Hun Mok(Trinity College Dublin)Philip Newsholme(University College Dublin)Gabriel Nuñez(University of Michigan–Ann Arbor)Junji Yodoi(Kyoto University)Steven E. Kahn(VA Puget Sound Health Care System)Ed C. Lavelle(Trinity College Dublin)Luke O'neill(Trinity College Dublin)

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Pancreatitis Pathology and Treatment Inflammasome and immune disorders Diabetes and associated disordersInflammasomeIsletAmyloid (mycology)AmylinType 2 diabetesGenetically modified mouseEndocrinologyPathogenesisChemistryPancreatic islets

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAmyloidAnimalsCarrier ProteinsCells, CulturedDendritic CellsDiabetes Mellitus, Type 2GlyburideHumansHypoglycemic AgentsIslets of LangerhansMacrophagesMice, Inbred C57BLMice, TransgenicReceptors, Cytoplasmic and Nuclear

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Initiation and perpetuation of <scp>NLRP</scp>3 inflammasome activation and assembly