review Open AccessTop 1% cited
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Nature reviews. Immunology · 2019 · Vol. 19(8) · pp. 477–489
Karen V. Swanson✉(University of North Carolina at Chapel Hill)Meng Deng(University of North Carolina at Chapel Hill)Jenny P.‐Y. Ting(University of North Carolina at Chapel Hill)
Inflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideStreptococcal Infections and TreatmentsInflammasomePyrin domainCell biologyIntracellularNodChemistryCaspase 1NALP3PyroptosisProgrammed cell death
MeSH terms
PyroptosisNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCalciumChloridesHumansMitochondriaPhosphorylationPotassiumUbiquitinationInflammasomes
Funding
- National Institutes of Health
- National Center for Advancing Translational Sciences
Citations
4,394
FWCI
151.27
field-weighted impact
References
185
Percentile
100%
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Citations per year
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References
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Nature Medicine · 2015 · 3,158 citations
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Cell Death and Differentiation · 2007 · 1,418 citations
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Immunity · 2012 · 2,103 citations
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Nature Immunology · 2010 · 1,297 citations
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Nature Immunology · 2011 · 1,739 citations
Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
Biochemical Pharmacology · 2008 · 725 citations
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Immunity · 2013 · 2,085 citations
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