reviewTop 1% cited
Targeting the NLRP3 inflammasome in inflammatory diseases
Nature Reviews Drug Discovery · 2018 · Vol. 17(8) · pp. 588–606
Matthew Mangan✉(German Center for Neurodegenerative Diseases)Edward J. Olhava(Ifm Therapeutics (United States))William Roush(Ifm Therapeutics (United States))H. Martin Seidel(Ifm Therapeutics (United States))Gary D. Glick(Ifm Therapeutics (United States))Eicke Latz(University of Massachusetts Chan Medical School)
Inflammasome and immune disordersinterferon and immune responsesIL-33, ST2, and ILC PathwaysInflammasomePyrin domainCaspase 1NodInnate immune systemDrug discoveryPyroptosisInflammationReceptorCell biology
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References
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Cell Death and Differentiation · 2007 · 1,418 citations
Regulation of inflammasome activation
Immunological Reviews · 2015 · 1,061 citations
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Immunity · 2012 · 2,103 citations
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Nature Immunology · 2010 · 1,297 citations
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Cell Death and Differentiation · 2007 · 1,018 citations
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Immunity · 2013 · 2,085 citations
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Nature Reviews Drug Discovery · 2012 · 1,731 citations
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
The Journal of Immunology · 2009 · 2,835 citations
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