article Open AccessTop 1% cited
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Nature Immunology · 2008 · Vol. 9(8) · pp. 847–856
Veit Hornung✉(University of Massachusetts Chan Medical School)Franz Bauernfeind(Ludwig-Maximilians-Universität München)Annett Halle(University of Massachusetts Chan Medical School)Eivind Ottersen Samstad(Norwegian University of Science and Technology)Hajime Kono(University of Massachusetts Chan Medical School)Kenneth L. Rock(University of Massachusetts Chan Medical School)Katherine A. Fitzgerald(University of Massachusetts Chan Medical School)Eicke Latz(University of Massachusetts Chan Medical School)
Inflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideNeonatal Health and BiochemistryNALP3InflammasomeCathepsin BCathepsinChemistryInflammationPhagosomeCell biologyPhagocytosisLysosome
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCarrier ProteinsInflammationMacrophagesMice, Inbred C57BLSilicon DioxideSilicosisAluminum CompoundsInflammation MediatorsMice
Citations
2,984
FWCI
60.82
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
Cited by
Initiation and perpetuation of <scp>NLRP</scp>3 inflammasome activation and assembly
Immunological Reviews · 2015 · 832 citations
Regulation of inflammasome activation
Immunological Reviews · 2015 · 1,061 citations
The inflammasome: an integrated view
Immunological Reviews · 2011 · 772 citations
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Molecules · 2020 · 1,266 citations
Innate immunity to virus infection
Immunological Reviews · 2008 · 1,214 citations
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Annual Review of Immunology · 2011 · 1,588 citations
Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Frontiers in Immunology · 2018 · 719 citations
The Inflammasomes: Guardians of the Body
Annual Review of Immunology · 2009 · 2,393 citations
References
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Cell Death and Differentiation · 2007 · 1,418 citations
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis
Free Radical Biology and Medicine · 2003 · 919 citations
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
Nature Immunology · 2004 · 1,343 citations
Toll-Like Receptors
Annual Review of Immunology · 2003 · 6,131 citations
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
The EMBO Journal · 2006 · 1,427 citations
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Immunity · 2004 · 1,736 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.