articleTop 1% cited
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Immunity · 2013 · Vol. 38(6) · pp. 1142–1153
Raúl Muñoz-Planillo(University of Michigan)Peter Kuffa(University of Michigan)Giovanny J. Martínez-Colón(University of Michigan)Brenna L. Smith(University of Michigan)Thekkelnaycke M. Rajendiran(University of Michigan)Gabriel Núñez✉(University of Michigan)
Inflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideGout, Hyperuricemia, Uric AcidInflammasomeEffluxBiologyMicrobial toxinsParticulatesMicrobiologyImmunologyBiochemistryInflammationToxin
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAdenosine TriphosphateAnimalsCarrier ProteinsCell Membrane PermeabilityCells, CulturedEnzyme ActivationImmunity, InnateMacrophagesMice, Inbred C57BLMitochondriaNigericinPotassiumPotassium ChannelsSodium Channels
Funding
- National Institutes of Health
Citations
2,085
FWCI
45.90
field-weighted impact
References
43
Percentile
100%
vs. same field & year
Citations per year
Cited by
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Circulation Research · 2018 · 1,950 citations
Initiation and perpetuation of <scp>NLRP</scp>3 inflammasome activation and assembly
Immunological Reviews · 2015 · 832 citations
Regulation of inflammasome activation
Immunological Reviews · 2015 · 1,061 citations
Pyroptotic cell death defends against intracellular pathogens
Immunological Reviews · 2015 · 1,027 citations
NLRP3 inflammasome: Its regulation and involvement in atherosclerosis
Journal of Cellular Physiology · 2017 · 480 citations
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
International Journal of Molecular Sciences · 2019 · 3,306 citations
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K <sup>+</sup> efflux
European Journal of Immunology · 2015 · 502 citations
Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
Cell Death and Disease · 2019 · 1,264 citations
References
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Cell Death and Differentiation · 2007 · 1,418 citations
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Immunity · 2012 · 2,103 citations
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
Nature reviews. Immunology · 2010 · 1,789 citations
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
The EMBO Journal · 2006 · 1,427 citations
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
The Journal of Immunology · 2009 · 2,835 citations
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Nature Immunology · 2008 · 2,984 citations
The Inflammasomes
Cell · 2010 · 5,320 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.