article Open AccessTop 1% cited
Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity
Immunity · 2009 · Vol. 31(2) · pp. 331–341
Caroline E. Sutton✉(Trinity College Dublin)Stephen J. Lalor(Trinity College Dublin)Cheryl Sweeney(Trinity College Dublin)Corinna F. Brereton(Trinity College Dublin)Ed C. Lavelle(Trinity College Dublin)Kingston H. G. Mills(Trinity College Dublin)
Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesImmunodeficiency and Autoimmune DisordersBiologyInterleukin 23AutoimmunityInterleukin 17ImmunologyInterleukin 15InterleukinCell biologyInflammationCytokine
MeSH terms
Interleukin-22Interleukin-21AnimalsDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalT-Lymphocytes, Helper-InducerInterleukinsLipopolysaccharidesMice, Inbred C57BLMycobacterium tuberculosisReceptors, Thyroid HormoneAutoimmunityT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-deltaCD3 Complex
Citations
1,523
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41
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100%
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References
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
The Journal of Immunology · 2002 · 1,281 citations
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Nature Immunology · 2008 · 1,267 citations
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Nature Immunology · 2005 · 4,203 citations
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
The Journal of Experimental Medicine · 2005 · 4,029 citations
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Nature Immunology · 2007 · 2,108 citations
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Nature Immunology · 2005 · 4,662 citations
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Immunity · 2006 · 3,566 citations
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Cell · 2006 · 5,064 citations
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