review Open AccessTop 1% cited

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

Cell Metabolism · 2008 · Vol. 7(1) · pp. 11–20

Ralph J. DeBerardinis✉(University of Pennsylvania)Julian J. Lum(University of Pennsylvania)Georgia Hatzivassiliou(University of Pennsylvania)Craig B. Thompson(University of Pennsylvania)

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Cancer, Hypoxia, and Metabolism Mitochondrial Function and Pathology Metabolism, Diabetes, and CancerReprogrammingCancerCell growthBiologyCell biologyCell metabolismCancer researchCellComputational biologyGenetics

MeSH terms

AnimalsHumansModels, BiologicalNeoplasmsSignal TransductionPhosphatidylinositol 3-KinasesCell ProliferationHypoxia-Inducible Factor 1

Funding

Damon Runyon Cancer Research Foundation
National Institutes of Health

Citations

4,067

FWCI

51.13

field-weighted impact

References

Percentile

100%

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Citations per year

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References

Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

JNCI Journal of the National Cancer Institute · 2005 · 1,568 citations

Targeting HIF-1 for cancer therapy

Nature reviews. Cancer · 2003 · 6,642 citations

Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

The American Journal of Human Genetics · 2001 · 1,089 citations

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Cell Metabolism · 2006 · 2,210 citations

PI3K/Akt and apoptosis: size matters

Oncogene · 2003 · 1,174 citations

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Cell Metabolism · 2006 · 3,827 citations

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Cancer Cell · 2005 · 2,043 citations

Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas

International Journal of Cancer · 1995 · 836 citations

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