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Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer
JNCI Journal of the National Cancer Institute · 2005 · Vol. 97(9) · pp. 643–655
Federico Cappuzzo✉(Ospedale Bellaria)Fred R. Hirsch(Consorzio Interuniversitario Nazionale per l'Informatica)Elisa Rossi(Ospedale Bellaria)Stefania Bartolini(Consorzio Interuniversitario Nazionale per l'Informatica)Giovanni Luca Ceresoli(University of Colorado Health)Lynne Bemis(University of Colorado Health)Jerry Haney(University of Colorado Health)Samir E. Witta(University of Colorado Denver)Kathleen D. Danenberg(University of Colorado Health)I. Domenichini(University of Colorado Cancer Center)Vienna Ludovini(Consorzio Interuniversitario Nazionale per l'Informatica)Elisabetta Magrini(University of Colorado Health)Vanesa Gregorc(University of Colorado Denver)Claudio Doglioni(Ospedale Bellaria)Angelo Sidoni(University of Colorado Cancer Center)Maurizio Tonato(Ospedale Bellaria)Wilbur A. Franklin(San Raffaele University of Rome)Lucio Crinò(Ospedale Bellaria)Paul A. Bunn(Consorzio Interuniversitario Nazionale per l'Informatica)Marileila Varella‐Garcia(Ospedale Bellaria)
Abstract
High EGFR gene copy number identified by FISH may be an effective molecular predictor for gefitinib efficacy in advanced NSCLC.
Lung Cancer Treatments and MutationsColorectal Cancer Treatments and StudiesHER2/EGFR in Cancer ResearchGefitinibEpidermal growth factor receptorLung cancerCancer researchGeneEpidermal growth factorBiologyCancerReceptorOncology
MeSH terms
GefitinibAdultAgedAntineoplastic AgentsCarcinoma, Non-Small-Cell LungFemaleHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedPredictive Value of TestsProto-Oncogene ProteinsQuinazolinesResearch Design
Citations
1,568
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47
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References
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