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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Cell stem cell · 2013 · Vol. 12(1) · pp. 49–61

Keiyo Takubo✉(Keio University)Go Nagamatsu(Keio University)Chiharu I. Kobayashi(Keio University)Ayako Nakamura‐Ishizu(Keio University)Hiroshi Kobayashi(Keio University)Eiji Ikeda(Yamaguchi University)Nobuhito Goda(Japan Science and Technology Agency)Yasmeen Rahimi(Indiana University School of Medicine)Randall S. Johnson(University of Cambridge)Tomoyoshi Soga(Keio University)Atsushi Hirao(Japan Science and Technology Agency)Makoto Suematsu(Japan Science and Technology Agency)Toshio Suda✉(Keio University)

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Cancer, Hypoxia, and Metabolism Pancreatic function and diabetes Hematopoietic Stem Cell TransplantationBiologyCell biologyStem cellGlycolysisHaematopoiesisHematopoietic stem cellCell cycleCell cycle checkpointCancer researchCell

MeSH terms

Pyruvate Dehydrogenase Acetyl-Transferring KinaseAnimalsCell CycleCells, CulturedFlow CytometryGlycolysisHematopoietic Stem CellsImmunohistochemistryMice, Mutant StrainsModels, BiologicalProtein Serine-Threonine KinasesReactive Oxygen SpeciesMice

Citations

781

FWCI

19.34

field-weighted impact

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100%

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References

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype