reviewTop 1% cited
PI3K/Akt and apoptosis: size matters
Oncogene · 2003 · Vol. 22(56) · pp. 8983–8998
Thomas Franke✉(Columbia University)Christoph Hornik(Columbia University)Lisa Segev(Columbia University)Grigoriy A Shostak(Columbia University)Chizuru Sugimoto(Columbia University)
PI3K/AKT/mTOR signaling in cancerFOXO transcription factor regulationCancer Mechanisms and TherapyProtein kinase BPI3K/AKT/mTOR pathwayBiologyAKT3AKT1Signal transductionProto-Oncogene Proteins c-aktCancer researchKinaseCell biology
MeSH terms
AnimalsCell SurvivalHumansModels, GeneticPhosphoric Monoester HydrolasesProto-Oncogene ProteinsSignal TransductionTumor Suppressor Protein p53ApoptosisProtein Serine-Threonine KinasesPhosphatidylinositol 3-KinasesModels, AnimalTumor Suppressor ProteinsProto-Oncogene Proteins c-aktPTEN Phosphohydrolase
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References
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Trends in Biochemical Sciences · 2001 · 1,178 citations
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Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas
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The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · 1,548 citations
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell · 1997 · 5,689 citations
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