article Open AccessTop 1% cited
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Cell Metabolism · 2006 · Vol. 3(3) · pp. 177–185
Jung‐whan Kim(Johns Hopkins University)Irina Tchernyshyov(Johns Hopkins University)Gregg L. Semenza(Johns Hopkins University)Chi V. Dang✉(Johns Hopkins University)
Cancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMetabolism, Diabetes, and CancerHypoxia (environmental)Pyruvate kinasePyruvate dehydrogenase complexCell biologyPyruvate dehydrogenase kinasePKM2Metabolic adaptationCellular adaptationAdaptation (eye)Chemistry
MeSH terms
Pyruvate Dehydrogenase Acetyl-Transferring KinaseAdaptation, PhysiologicalAnimalsCell SurvivalFibroblastsHumansModels, BiologicalPhosphorylationProtein KinasesCell HypoxiaGene ExpressionGene Expression Regulation, EnzymologicApoptosisProtein Serine-Threonine KinasesReactive Oxygen Species
Funding
- National Institutes of Health
Citations
3,827
FWCI
42.65
field-weighted impact
References
26
Percentile
100%
vs. same field & year
Citations per year
Cited by
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Circulation Research · 2018 · 1,950 citations
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia
American Journal of Physiology-Cell Physiology · 2015 · 485 citations
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
Clinical Cancer Research · 2009 · 964 citations
Metabolic Modulation of Glioblastoma with Dichloroacetate
Science Translational Medicine · 2010 · 711 citations
The Warburg effect: 80 years on
Biochemical Society Transactions · 2016 · 501 citations
The Warburg Effect 97 Years after Its Discovery
Cancers · 2020 · 308 citations
Cancer's Molecular Sweet Tooth and the Warburg Effect
Cancer Research · 2006 · 1,214 citations
c-Myc and Cancer Metabolism
Clinical Cancer Research · 2012 · 844 citations
References
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Cell Metabolism · 2006 · 2,210 citations
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
Biochemical Society Transactions · 2003 · 471 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development · 1998 · 2,467 citations
A comparison of normalization methods for high densityoligonucleotide array data based on variance and bias
Bioinformatics · 2003 · 8,399 citations
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Cancer Research · 2004 · 1,453 citations
Oncogenic alterations of metabolism
Trends in Biochemical Sciences · 1999 · 1,095 citations
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Cell Metabolism · 2005 · 1,498 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.