reviewTop 1% cited
Targeting HIF-1 for cancer therapy
Nature reviews. Cancer · 2003 · Vol. 3(10) · pp. 721–732
Gregg L. Semenza✉(Johns Hopkins Medicine)
Cancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMetabolism, Diabetes, and CancerAngiogenesisHIF1AHypoxia (environmental)Cancer researchTranscription factorHypoxia-Inducible Factor 1Hypoxia-inducible factorsCancerBiologyCancer cell
MeSH terms
AnimalsDisease Models, AnimalDNA-Binding ProteinsHumansNeoplasmsNuclear ProteinsTranscription FactorsMiceHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha Subunit
Citations
6,642
FWCI
81.30
field-weighted impact
References
108
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100%
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References
Hypoxia — a key regulatory factor in tumour growth
Nature reviews. Cancer · 2002 · 5,147 citations
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
American Journal of Physiology-Cell Physiology · 1996 · 1,209 citations
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Genes & Development · 2002 · 1,520 citations
Purification and Characterization of Hypoxia-inducible Factor 1
Journal of Biological Chemistry · 1995 · 2,061 citations
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
Cancer Cell · 2003 · 1,293 citations
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology · 2000 · 1,298 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development · 1998 · 2,467 citations
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