article Open AccessTop 1% cited

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

Nature Cell Biology · 2015 · Vol. 17(2) · pp. 183–194

Miranda Fong✉(City of Hope)Weiying Zhou(City of Hope)Liang Liu(City of Hope)Aileen Y. Alontaga(Beckman Research Institute)Manasa Chandra(Beckman Research Institute)Jonathan Ashby(University of California, Riverside)Amy Chow(City of Hope)Sean Timothy Francis O’Connor(Beckman Research Institute)Shasha Li(City of Hope)Andrew R. Chin(Beckman Research Institute)George Somlo(City Of Hope National Medical Center)Melanie R. Palomares(City Of Hope National Medical Center)Zhuo Li(City of Hope)Jacob R. Tremblay(City of Hope)Akihiro Tsuyada(Beckman Research Institute)Guoqiang Sun(Beckman Research Institute)Michael A. Reid(City of Hope)Xiwei Wu(City of Hope)Piotr Swiderski(City of Hope)Xiubao Ren(Tianjin Medical University Cancer Institute and Hospital)Yanhong Shi(Beckman Research Institute)Mei Kong(Beckman Research Institute)Wenwan Zhong(University of California, Riverside)Chen Yuan(City of Hope)Shizhen Emily Wang(Tianjin Medical University Cancer Institute and Hospital)

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MicroRNA in disease regulation Extracellular vesicles in disease RNA modifications and cancerMetastasisCancer cellBiologyGlycolysisCell biologyCancer researchCancerMicrovesiclesGlucose uptakeMetabolism

MeSH terms

AstrocytesBase SequenceBreast NeoplasmsBromodeoxyuridineFemaleFibroblastsGlucoseHumansLuciferasesLungMolecular Sequence DataNeoplasm MetastasisPyruvate KinaseDown-RegulationMicroRNAs

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Characteristics and Significance of the Pre-metastatic Niche