article Open AccessTop 1% cited
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Cancer Cell · 2005 · Vol. 7(1) · pp. 77–85
Mary Selak✉(Cancer Research UK Scotland Institute)Sean M. Armour(University of Pennsylvania)Elaine D. MacKenzie(Cancer Research UK Scotland Institute)Houda Boulahbel(Cancer Research UK Scotland Institute)David G. Watson(University of Strathclyde)Kyle D. Mansfield(Cancer Research Institute)Yi Pan(University of Pennsylvania)M. Celeste Simon(University of Pennsylvania)Craig B. Thompson(University of Pennsylvania)Eyal Gottlieb(Cancer Research UK Scotland Institute)
Cancer, Hypoxia, and MetabolismAdrenal and Paraganglionic TumorsMitochondrial Function and PathologyCitric acid cycleFumaraseCytosolSuccinate dehydrogenaseMitochondrionCarcinogenesisTricarboxylic acidEnzymeBiologyBiochemistry
MeSH terms
AnimalsCell LineCell Transformation, NeoplasticCitric Acid CycleEnzyme ActivationHumansMitochondriaOncogenesProcollagen-Proline DioxygenaseSuccinate DehydrogenaseTranscription FactorsSignal TransductionGene Expression Regulation, EnzymologicReactive Oxygen SpeciesSuccinic Acid
Funding
- Beatson Institute for Cancer Research
Citations
2,043
FWCI
29.90
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
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References
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Genes & Development · 2002 · 1,520 citations
Regulation of angiogenesis by hypoxia: role of the HIF system
Nature Medicine · 2003 · 2,499 citations
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Cancer Cell · 2003 · 1,293 citations
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