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Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Cell stem cell · 2011 · Vol. 9(4) · pp. 298–310
Toshio Suda✉(Keio University)Keiyo Takubo(Keio University)Gregg L. Semenza(Johns Hopkins University)
Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and MetabolismMesenchymal stem cell researchBiologyHaematopoiesisNicheStem cellCell biologyStem cell nicheHematopoietic stem cellMetabolic regulationImmunologyMetabolism
MeSH terms
Cell CycleHematopoietic Stem CellsHumansSignal TransductionCell HypoxiaStem Cell NicheCellular Microenvironment
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References
Hematopoietic Stem Cells
American Journal Of Pathology · 2006 · 738 citations
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Nature Cell Biology · 2011 · 6,906 citations
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
Cell stem cell · 2010 · 1,071 citations
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
Molecular Cell · 2008 · 3,185 citations
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Cancer Cell · 2010 · 1,966 citations
Purification and Characterization of Hypoxia-inducible Factor 1
Journal of Biological Chemistry · 1995 · 2,061 citations
Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
Molecular Cell · 2004 · 1,282 citations
Reversal of human cellular senescence: roles of the p53 and p16 pathways
The EMBO Journal · 2003 · 1,414 citations
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