article Open AccessTop 1% cited
Reversal of human cellular senescence: roles of the p53 and p16 pathways
The EMBO Journal · 2003 · Vol. 22(16) · pp. 4212–4222
Christian Beauséjour✉(Lawrence Berkeley National Laboratory)
Telomeres, Telomerase, and SenescenceRetinal Development and DisordersDNA Repair MechanismsSenescenceBiologyTelomereTelomeraseCell biologyCarcinogenesisCell growthCell cycleTelomerase reverse transcriptaseCell division
MeSH terms
BreastCell LineEpithelial CellsFibroblastsHumansLuminescent ProteinsModels, BiologicalGenes, rasSignal TransductionTumor Suppressor Protein p53Lentivirus InfectionsCellular SenescenceTelomeraseCyclin-Dependent Kinase Inhibitor p16Green Fluorescent Proteins
Funding
- Uehara Memorial Foundation
Citations
1,414
FWCI
18.20
field-weighted impact
References
61
Percentile
100%
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Citations per year
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References
A role for both RB and p53 in the regulation of human cellular senescence*1
Experimental Cell Research · 1991 · 746 citations
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Cell · 1997 · 5,018 citations
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Current Biology · 1998 · 1,005 citations
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences · 1995 · 7,364 citations
CDK inhibitors: positive and negative regulators of G1-phase progression
Genes & Development · 1999 · 6,077 citations
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
Genes & Development · 2002 · 1,548 citations
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Journal of Virology · 1998 · 3,348 citations
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