review Open AccessTop 1% cited

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

Molecular Cell · 2008 · Vol. 30(4) · pp. 393–402

William G. Kaelin✉(Howard Hughes Medical Institute)Peter J. Ratcliffe✉(University of Oxford)

Cancer, Hypoxia, and Metabolism High Altitude and Hypoxia Adrenal and Paraganglionic TumorsBiologyHydroxylationReactive oxygen speciesCell biologyNitric oxideSignal transductionEnzymeIntracellularOxygenMetabolism

MeSH terms

AnimalsAscorbic AcidAsparagineCitric Acid CycleEnzyme StabilityGene Expression RegulationHumansMixed Function OxygenasesIronIsoenzymesNitric OxideOxygenProcollagen-Proline DioxygenaseRepressor ProteinsTranscription Factors

Funding

FibroGen

Citations

3,185

FWCI

48.20

field-weighted impact

References

113

Percentile

100%

vs. same field & year

Citations per year

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References

Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

Molecular and Cellular Biology · 2005 · 929 citations

Targeting HIF-1 for cancer therapy

Nature reviews. Cancer · 2003 · 6,642 citations

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

The EMBO Journal · 2003 · 1,329 citations

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Cancer Cell · 2005 · 2,043 citations

Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Genes & Development · 1998 · 2,467 citations

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Molecular and Cellular Biology · 2003 · 1,370 citations

Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State

Developmental Cell · 2005 · 1,098 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

The EMBO Journal · 1998 · 1,593 citations

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