reviewTop 1% cited
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Trends in Pharmacological Sciences · 2012 · Vol. 33(4) · pp. 207–214
Gregg L. Semenza✉(Johns Hopkins Medicine)
Cancer, Hypoxia, and MetabolismNeuroblastoma Research and TreatmentsMitochondrial Function and PathologyHypoxia (environmental)AngiogenesisRadiation therapyMetastasisMedicineCancer researchHIF1AChemotherapyCancerClinical trial
MeSH terms
AnimalsAntineoplastic AgentsHumansNeoplasmsCell HypoxiaDisease ProgressionHypoxia-Inducible Factor 1Molecular Targeted Therapy
Funding
- American Cancer Society
- Johns Hopkins University
Citations
1,508
FWCI
43.37
field-weighted impact
References
93
Percentile
100%
vs. same field & year
Citations per year
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References
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
Cancer Cell · 2009 · 1,697 citations
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
Cardiovascular Research · 2010 · 531 citations
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
Molecular Cell · 2008 · 3,185 citations
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Cell stem cell · 2011 · 823 citations
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Molecular Cell · 2010 · 2,357 citations
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Oncogene · 2009 · 1,685 citations
Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
Cancer Cell · 2009 · 2,332 citations
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Cancer Cell · 2007 · 1,511 citations
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