article Open AccessTop 1% cited

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Nature Cell Biology · 2011 · Vol. 13(2) · pp. 132–141

Joungmok Kim✉Mondira Kundu(St. Jude Children's Research Hospital)Benoı̂t Viollet(Délégation Paris 5)Kun‐Liang Guan(Moores Cancer Center)

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Autophagy in Disease and Therapy Metabolism, Diabetes, and Cancer Pancreatic function and diabetesAutophagyULK1AMPKCell biologyPI3K/AKT/mTOR pathwayAutophagy-related protein 13BAG3BiologyPhosphorylationKinase

MeSH terms

Autophagy-Related Protein-1 HomologAnimalsAutophagyGlucoseHumansPhosphorylationSerineProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsMiceAMP-Activated Protein KinasesHEK293 CellsTOR Serine-Threonine Kinases

Funding

National Institutes of Health

Citations

6,906

FWCI

159.47

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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References

Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion

Circulation Research · 2007 · 1,476 citations

Autophagosome formation: core machinery and adaptations

Nature Cell Biology · 2007 · 2,136 citations

mTOR regulation of autophagy

FEBS Letters · 2010 · 2,076 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology · 2002 · 3,038 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Genes & Development · 2003 · 1,900 citations

The role of the Atg1/ULK1 complex in autophagy regulation

Current Opinion in Cell Biology · 2010 · 1,050 citations

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Molecular Cell · 2008 · 3,735 citations

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Journal of Cell Science · 2006 · 799 citations

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Molecular Biology of the Cell · 2009 · 2,009 citations

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