article Open AccessTop 1% cited
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Cancer Cell · 2010 · Vol. 17(3) · pp. 225–234
Patrick S. Ward✉(University of Pennsylvania)Jay Patel(Memorial Sloan Kettering Cancer Center)David R. Wise(University of Pennsylvania)Omar Abdel‐Wahab(Memorial Sloan Kettering Cancer Center)Bryson D. Bennett(Princeton University)Hilary A. Coller(Princeton University)Justin R. Cross(University of Pennsylvania)Valeria R. Fantin(Agios Pharmaceuticals (United States))Cyrus V. Hedvat(Memorial Sloan Kettering Cancer Center)Alexander E. Perl(University of Pennsylvania)Joshua D. Rabinowitz(Princeton University)Martin Carroll(University of Pennsylvania)Shinsan M. Su(Agios Pharmaceuticals (United States))Kim A. Sharp(University of Pennsylvania)Ross L. Levine(Memorial Sloan Kettering Cancer Center)Craig B. Thompson(University of Pennsylvania)
Acute Myeloid Leukemia ResearchCancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentIDH1IDH2EnzymeBiologyIsocitrate dehydrogenaseBiochemistryFeature (linguistics)LeukemiaCell biologyMutation
MeSH terms
GlutaratesHumansIsocitrate DehydrogenaseIsocitratesKetoglutaric AcidsMitochondriaMutationTumor Cells, CulturedLeukemia, Myeloid, AcuteCell Proliferation
Funding
- Howard Hughes Medical Institute
- University of Pennsylvania
- Memorial Sloan-Kettering Cancer Center
- Agios Pharmaceuticals
- National Cancer Institute
Citations
1,966
FWCI
71.80
field-weighted impact
References
27
Percentile
100%
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Citations per year
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References
The PyMOL Molecular Graphics System
Medical Entomology and Zoology · 2002 · 18,132 citations
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry
Journal of Chromatography A · 2006 · 590 citations
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
Acta Neuropathologica · 2009 · 1,148 citations
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