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Gregg L. Semenza

Johns Hopkins MedicineORCID https://orcid.org/0000-0002-0913-211X
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Top Publications

Targeting HIF-1 for cancer therapy
Nature reviews. Cancer20036,642 citationsFirst authorCorresponding
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences19956,172 citations
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
Molecular and Cellular Biology19963,948 citationsCorresponding
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Cell Metabolism20063,827 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development19982,467 citationsCorresponding
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Molecular and Cellular Biology19922,445 citationsFirst authorCorresponding
Purification and Characterization of Hypoxia-inducible Factor 1
Journal of Biological Chemistry19952,061 citationsCorresponding
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
Journal of Applied Physiology20001,817 citationsFirst authorCorresponding
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Oncogene20091,685 citationsFirst authorCorresponding
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Trends in Pharmacological Sciences20121,508 citationsFirst authorCorresponding
HIF-1 and mechanisms of hypoxia sensing
Current Opinion in Cell Biology20011,266 citationsFirst authorCorresponding
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
Molecular and Cellular Biology20011,245 citations
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
American Journal of Physiology-Cell Physiology19961,209 citations
Oncogenic alterations of metabolism
Trends in Biochemical Sciences19991,095 citations
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
Molecular and Cellular Biology1992912 citationsFirst authorCorresponding
Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology2002849 citationsFirst authorCorresponding
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Cell stem cell2011823 citations
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
Cardiovascular Research2010531 citations
Expression of hypoxia-inducible factor 1: mechanisms and consequences
Biochemical Pharmacology2000508 citationsFirst authorCorresponding
Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
The Journal of Pathology2001491 citations