article Open AccessTop 1% cited
Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
Molecular Cell · 2004 · Vol. 14(4) · pp. 501–513
Utz Herbig(Brown University)Wendy A. Jobling(Brown University)Benjamin P.C. Chen(Lawrence Berkeley National Laboratory)David Chen(Lawrence Berkeley National Laboratory)John M. Sedivy✉(Brown University)
Telomeres, Telomerase, and SenescenceDNA Repair MechanismsGenetics, Aging, and Longevity in Model OrganismsTelomereBiologySenescenceCell biologyCell cycle checkpointCell cycleDNA damageCHEK1G2-M DNA damage checkpointSignal transduction
MeSH terms
Cell LineDNA DamageDNA-Binding ProteinsHumansStress, PhysiologicalSignal TransductionUp-RegulationTumor Suppressor Protein p53G1 PhaseG2 PhaseCyclinsTelomereCellular SenescenceCell DeathProtein Serine-Threonine Kinases
Funding
- Israel National Road Safety Authority
- National Institutes of Health
Citations
1,282
FWCI
29.74
field-weighted impact
References
39
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100%
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Citations per year
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References
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Oncogene · 2002 · 922 citations
DNA Damage Foci at Dysfunctional Telomeres
Current Biology · 2003 · 1,393 citations
Reversal of human cellular senescence: roles of the p53 and p16 pathways
The EMBO Journal · 2003 · 1,414 citations
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Nature reviews. Cancer · 2003 · 2,539 citations
Sensing and repairing DNA double-strand breaks
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