reviewTop 1% cited
HIF-1 and mechanisms of hypoxia sensing
Current Opinion in Cell Biology · 2001 · Vol. 13(2) · pp. 167–171
Gregg L. Semenza✉(Johns Hopkins Hospital)
Cancer, Hypoxia, and MetabolismAdipose Tissue and MetabolismHigh Altitude and HypoxiaBiologyTransactivationCell biologyHypoxia (environmental)Hypoxia-Inducible Factor 1G alpha subunitSignal transductionHypoxia-inducible factorsNitric oxideActivator (genetics)
MeSH terms
AnimalsHypoxiaDNA-Binding ProteinsHumansNuclear ProteinsTranscription FactorsSignal TransductionHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha Subunit
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References
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
American Journal of Physiology-Cell Physiology · 1996 · 1,209 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Nature Cell Biology · 2000 · 1,582 citations
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