reviewTop 1% cited

Oncogenic alterations of metabolism

Trends in Biochemical Sciences · 1999 · Vol. 24(2) · pp. 68–72

Chi V. Dang✉(Johns Hopkins Medicine)Gregg L. Semenza(Johns Hopkins Medicine)

Cancer, Hypoxia, and Metabolism Metabolism, Diabetes, and Cancer Mitochondrial Function and PathologyGlycolysisBiologyCellular metabolismHypoxia (environmental)MetabolismCell biologyCancerCancer cellCarbohydrate metabolismCancer research

MeSH terms

AnimalsHypoxiaGlycolysisHumansLymphokinesNeoplasmsOncogenesGene Expression Regulation, NeoplasticGenes, Tumor SuppressorEndothelial Growth FactorsApoptosisVascular Endothelial Growth FactorsVascular Endothelial Growth Factor A

Funding

National Institutes of Health

Citations

1,095

FWCI

15.58

field-weighted impact

References

Percentile

99%

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Citations per year

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References

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

Cell · 1996 · 6,874 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Proceedings of the National Academy of Sciences · 1995 · 6,172 citations

Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Genes & Development · 1998 · 2,467 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

The EMBO Journal · 1998 · 1,593 citations

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