reviewTop 1% cited
Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology · 2002 · Vol. 64(5-6) · pp. 993–998
Gregg L. Semenza✉(Johns Hopkins University)
Cancer, Hypoxia, and MetabolismAdipose Tissue and MetabolismHigh Altitude and HypoxiaSignal transductionRegulatorAngiogenesisBiologyHypoxia (environmental)Cell biologyActivator (genetics)Hypoxia-Inducible Factor 1Cellular adaptationHypoxia-inducible factors
MeSH terms
AnimalsHypoxiaHumansNeoplasmsProto-Oncogene ProteinsTranscription FactorsSignal TransductionProtein Serine-Threonine KinasesCell Cycle ProteinsPhosphatidylinositol 3-KinasesMAP Kinase Signaling SystemProto-Oncogene Proteins c-aktHypoxia-Inducible Factor 1, alpha SubunitAtaxia Telangiectasia Mutated Proteins
Citations
849
FWCI
23.52
field-weighted impact
References
72
Percentile
100%
vs. same field & year
Citations per year
Cited by
Mitochondrial formation of reactive oxygen species
The Journal of Physiology · 2003 · 3,946 citations
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
Endocrine Reviews · 2004 · 3,664 citations
The biology of VEGF and its receptors
Nature Medicine · 2003 · 9,519 citations
Mitochondrial formation of reactive oxygen species
The Journal of Physiology · 2003 · 4,255 citations
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of<i>ob</i>/<i>ob</i>and dietary obese mice
American Journal of Physiology-Endocrinology and Metabolism · 2007 · 816 citations
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1
Journal of Clinical Pathology · 2004 · 771 citations
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
International Journal of Obesity · 2008 · 523 citations
Radiation-Induced Lung Injury (RILI)
Frontiers in Oncology · 2019 · 352 citations
References
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
American Journal of Physiology-Cell Physiology · 1996 · 1,209 citations
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology · 2000 · 1,298 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development · 1998 · 2,467 citations
HIF-1alpha is required for solid tumor formation and embryonic vascularization
The EMBO Journal · 1998 · 1,593 citations
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
Molecular and Cellular Biology · 2001 · 1,245 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.