reviewTop 1% cited

Role of GPX4 in ferroptosis and its pharmacological implication

Free Radical Biology and Medicine · 2018 · Vol. 133 · pp. 144–152

Tobias Seibt(LMU Klinikum)Bettina Proneth(Helmholtz Zentrum München)Marcus Conrad✉(Helmholtz Zentrum München)

Ferroptosis and cancer prognosis Cancer, Lipids, and Metabolism Drug Transport and Resistance MechanismsGPX4Programmed cell deathCancer cellGlutaminolysisContext (archaeology)Lipid peroxidationBiologyCell biologyApoptosisCancer research

MeSH terms

FerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsFatty Acids, UnsaturatedHumansIronNeoplasmsLipid PeroxidationCell DeathNeurodegenerative DiseasesMiceSmall Molecule Libraries

Funding

Human Frontier Science Program
Deutsche Forschungsgemeinschaft
Ludwig-Maximilians-Universität München

Citations

1,452

FWCI

38.12

field-weighted impact

References

111

Percentile

100%

vs. same field & year

Citations per year

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References

Glutaminolysis and Transferrin Regulate Ferroptosis

Molecular Cell · 2015 · 1,981 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Annals of Neurology · 1994 · 1,146 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

Journal of Neurochemistry · 1989 · 1,141 citations

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Cell · 2012 · 17,296 citations

Regulation of Ferroptotic Cancer Cell Death by GPX4

Cell · 2014 · 7,213 citations

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Cell Metabolism · 2008 · 1,415 citations

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Bioorganic & Medicinal Chemistry Letters · 2011 · 234 citations

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology · 2014 · 3,521 citations

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

Frontiers in Physiology · 2019 · 514 citations

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