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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Cell Metabolism · 2008 · Vol. 8(3) · pp. 237–248

Alexander Seiler(Helmholtz Zentrum München)Manuela Schneider(Helmholtz Zentrum München)Heidi Förster(Helmholtz Zentrum München)Stephan Roth(Charité - Universitätsmedizin Berlin)Eva K. Wirth(Charité - Universitätsmedizin Berlin)Carsten Culmsee(Philipps University of Marburg)Nikolaus PlesnilaElisabeth Kremmer(Helmholtz Zentrum München)Olof Rådmark(Karolinska Institutet)Wolfgang Wurst(Max Planck Institute of Psychiatry)Georg W. Bornkamm(Helmholtz Zentrum München)Ulrich Schweizer(Charité - Universitätsmedizin Berlin)Marcus Conrad✉(Helmholtz Zentrum München)

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Neutrophil, Myeloperoxidase and Oxidative Mechanisms Redox biology and oxidative stress Nitric Oxide and Endothelin EffectsGPX4Oxidative stressProgrammed cell deathGlutathioneCell biologyNeurodegenerationLipid peroxidationEx vivoPhospholipid-hydroperoxide glutathione peroxidaseChemistry

MeSH terms

Phospholipid Hydroperoxide Glutathione PeroxidaseAllelesAnimalsArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseCells, CulturedFluorenesGenotypeGlutathione PeroxidaseHippocampusHumansMice, Inbred C57BLNeuronsLipid PeroxidationCell Death

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