articleTop 1% cited

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology · 2014 · Vol. 16(12) · pp. 1180–1191

José Pedro Friedmann Angeli✉(Helmholtz Zentrum München)Manuela Schneider(Ludwig-Maximilians-Universität München)Bettina Proneth(Helmholtz Zentrum München)Yulia Y. Tyurina(University of Pittsburgh)Vladimir A. Tyurin(University of Pittsburgh)Victoria J. Hammond(Cardiff University)Nadja Herbach(Ludwig-Maximilians-Universität München)Michaela Aichler(Helmholtz Zentrum München)Axel Walch(Helmholtz Zentrum München)Elke EggenhoferDevaraj Basavarajappa(Karolinska Institutet)Olof Rådmark(Karolinska Institutet)Sho Kobayashi(Helmholtz Zentrum München)Tobias Seibt(Helmholtz Zentrum München)Heike Beck(Ludwig-Maximilians-Universität München)Frauke Neff(Helmholtz Zentrum München)Iréne Esposito(Technical University of Munich)Rüdiger Wanke(Ludwig-Maximilians-Universität München)Heidi Förster(Helmholtz Zentrum München)O. P. Yefremova(Helmholtz Zentrum München)Marc Heinrichmeyer(Helmholtz Zentrum München)Georg W. Bornkamm(Helmholtz Zentrum München)Edward K. GeisslerStephen B. Thomas(Howard Hughes Medical Institute)Brent R. Stockwell(Columbia University)Valerie B. O’Donnell(Cardiff University)Valerian E. Kagan(University of Pittsburgh)Joel Schick(Helmholtz Zentrum München)Marcus Conrad(Helmholtz Zentrum München)

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Ferroptosis and cancer prognosis Epigenetics and DNA Methylation Cancer, Lipids, and MetabolismGPX4Programmed cell deathCell biologyCytoprotectionApoptosisRegulatorCellBiologyAutophagyCancer research

MeSH terms

Phospholipid Hydroperoxide Glutathione PeroxidaseAnimalsArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseCardiolipinsCell LineGlutathione PeroxidaseHumansImidazolesIndolesKidneyMaleMice, Inbred C57BLMitochondriaPeroxidases

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Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells