article Open AccessTop 1% cited
Regulation of Ferroptotic Cancer Cell Death by GPX4
Cell · 2014 · Vol. 156(1-2) · pp. 317–331
Wan Seok Yang(Columbia University)Rohitha Sriramaratnam(Columbia University)Matthew Welsch(Columbia University)Kaoru Shimada(Columbia University)Rachid Skouta(Columbia University)Vasanthi S. Viswanathan(Broad Institute)Jaime H. Cheah(Broad Institute)Paul A. Clemons(Broad Institute)Alykhan F. Shamji(Broad Institute)Clary B. Clish(Broad Institute)Lewis M. Brown(Columbia University)Albert W. Girotti(Medical College of Wisconsin)Virginia W. Cornish(Columbia University)Stuart L. Schreiber(Broad Institute)Brent R. Stockwell✉(Howard Hughes Medical Institute)
Ferroptosis and cancer prognosisCancer, Lipids, and MetabolismCancer-related gene regulationBiologyProgrammed cell deathCancerGPX4Cell biologyAutophagyCancer cellCellCancer researchApoptosis
MeSH terms
Phospholipid Hydroperoxide Glutathione PeroxidaseAnimalsCarbolinesCarcinoma, Renal CellGlutathioneGlutathione PeroxidaseHumansNeoplasm TransplantationNeoplasmsPiperazinesLymphoma, B-CellCell DeathCell Line, TumorMiceGene Knockdown Techniques
Funding
- National Science Foundation
- New York State Stem Cell Science
- Broad Institute
- National Institutes of Health
- National Cancer Institute
- Division of Chemistry
Citations
7,213
FWCI
66.39
field-weighted impact
References
49
Percentile
100%
vs. same field & year
Citations per year
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References
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Cell · 2012 · 17,296 citations
Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
Cell Metabolism · 2008 · 1,415 citations
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
Bioorganic & Medicinal Chemistry Letters · 2011 · 234 citations
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Cancer Cell · 2003 · 1,396 citations
The NCI60 human tumour cell line anticancer drug screen
Nature reviews. Cancer · 2006 · 2,646 citations
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Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1995 · 106,483 citations
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Nature reviews. Cancer · 2007 · 2,924 citations
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