review Open AccessTop 1% cited
Targeting ferroptosis as a vulnerability in cancer
Nature reviews. Cancer · 2022 · Vol. 22(7) · pp. 381–396
Guang Lei(The University of Texas MD Anderson Cancer Center)Li Zhuang(The University of Texas MD Anderson Cancer Center)Boyi Gan✉(The University of Texas MD Anderson Cancer Center)
Ferroptosis and cancer prognosisRNA modifications and cancerCancer, Lipids, and MetabolismProgrammed cell deathCancerCancer cellApoptosisGPX4BiologyCancer researchVulnerability (computing)CellCell biology
MeSH terms
FerroptosisHumansIronNeoplasmsCell DeathApoptosis
Funding
- Emerson Collective
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
Citations
2,045
FWCI
303.57
field-weighted impact
References
204
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
Glutaminolysis and Transferrin Regulate Ferroptosis
Molecular Cell · 2015 · 1,981 citations
Metabolism and function of coenzyme Q
Biochimica et Biophysica Acta (BBA) - Biomembranes · 2003 · 1,018 citations
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Cell · 2012 · 17,296 citations
Regulation of Ferroptotic Cancer Cell Death by GPX4
Cell · 2014 · 7,213 citations
Glutathione: new roles in redox signaling for an old antioxidant
Frontiers in Pharmacology · 2014 · 834 citations
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Nature Cell Biology · 2014 · 3,521 citations
How mitochondria produce reactive oxygen species
Biochemical Journal · 2008 · 7,889 citations
A Comprehensive Survey of Ras Mutations in Cancer
Cancer Research · 2012 · 2,030 citations
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