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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Immunity · 2012 · Vol. 36(3) · pp. 401–414
Kenichi Shimada✉(Cedars-Sinai Medical Center)Timothy R. Crother(Cedars-Sinai Medical Center)Justin N. Karlin(Cedars-Sinai Medical Center)Jargalsaikhan Dagvadorj(Cedars-Sinai Medical Center)Norika Chiba(Cedars-Sinai Medical Center)Shuang Chen(Cedars-Sinai Medical Center)V. Krishnan Ramanujan(Cedars-Sinai Medical Center)Andrea J. Wolf(Cedars-Sinai Medical Center)Laurent Vergnes(University of California, Los Angeles)David M. Ojcius(University of California, Merced)Altan Rentsendorj(Cedars-Sinai Medical Center)Mario H. Vargas(University of California, Riverside)Candace Guerrero(University of California, Riverside)Yinsheng Wang(University of California, Riverside)Katherine A. Fitzgerald(University of Massachusetts Chan Medical School)David M. Underhill(Cedars-Sinai Medical Center)Terrence Town(Cedars-Sinai Medical Center)Moshe Arditi(Cedars-Sinai Medical Center)
Inflammasome and immune disordersinterferon and immune responsesImmune Response and InflammationInflammasomeApoptosisMitochondrial DNACytosolMitochondrionCell biologyAIM2BiologyProgrammed cell deathMitochondrial ROS
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCarrier ProteinsDNA, MitochondrialMacrophagesMice, Inbred C57BLOxidation-ReductionSalmonella typhimuriumSignal TransductionGene ExpressionNF-kappa BApoptosisMice, KnockoutProto-Oncogene Proteins c-bcl-2Mice
Funding
- Rheinische Friedrich-Wilhelms-Universität Bonn
- National Institutes of Health
Citations
2,103
FWCI
41.61
field-weighted impact
References
54
Percentile
100%
vs. same field & year
Citations per year
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References
Organelle-specific initiation of cell death pathways
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The inflammasome: an integrated view
Immunological Reviews · 2011 · 772 citations
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