article Open AccessTop 1% cited
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Cell Death and Differentiation · 2007 · Vol. 14(9) · pp. 1590–1604
Teresa Fernandes‐Alnemri✉(Thomas Jefferson University)Jiang Wu(Thomas Jefferson University)Je‐Wook Yu(Thomas Jefferson University)Pinaki Datta(Thomas Jefferson University)Bruce L. Miller(Thomas Jefferson University)W Jankowski(Thomas Jefferson University)Stephen Rosenberg(Thomas Jefferson University)Jianke Zhang(Thomas Jefferson University)Emad S. Alnemri(Thomas Jefferson University)
Inflammasome and immune disordersinterferon and immune responsesToxoplasma gondii Research StudiesPyroptosisInflammasomeProinflammatory cytokineCaspase 1Cell biologyChemistryCaspaseProgrammed cell deathIntracellularNALP3
MeSH terms
Cytoskeletal ProteinsEnzyme ActivationHumansInflammationLipopolysaccharidesMacrophagesPotassiumRecombinant Fusion ProteinsApoptosisMicroscopy, ConfocalDimerizationCaspase 1Adaptor Proteins, Signal Transducing
Funding
- National Institutes of Health
Citations
1,018
FWCI
15.28
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References
43
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99%
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References
The Inflammasome
Molecular Cell · 2002 · 5,936 citations
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
The EMBO Journal · 2006 · 1,427 citations
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Immunity · 2004 · 1,736 citations
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Infection and Immunity · 2005 · 2,191 citations
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