article Open AccessTop 1% cited
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
International Journal of Epidemiology · 2017 · Vol. 46(6) · pp. 1985–1998
Fernando Pires Hartwig✉(MRC Integrative Epidemiology Unit)George Davey Smith(MRC Integrative Epidemiology Unit)Jack Bowden(MRC Integrative Epidemiology Unit)
Abstract
The MBE relaxes the instrumental variable assumptions, and should be used in combination with other approaches in sensitivity analyses.
Genetic Associations and EpidemiologyAdvanced Causal Inference TechniquesGenetic and phenotypic traits in livestockMendelian randomizationInstrumental variablePleiotropyCausal inferenceGenome-wide association studySample size determinationStatisticsInferenceGenetic associationEconometrics
MeSH terms
HumansModels, StatisticalCausalitySample SizeGenome-Wide Association StudyMendelian Randomization AnalysisGenetic Pleiotropy
Funding
- University of Bristol
- Medical Research Council
Citations
3,604
FWCI
78.39
field-weighted impact
References
29
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100%
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Citations per year
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Nature Genetics · 2013 · 3,254 citations
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International Journal of Epidemiology · 2016 · 1,697 citations
A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
Statistics in Medicine · 2017 · 1,983 citations
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
International Journal of Epidemiology · 2016 · 919 citations
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