article Open AccessTop 1% cited

Discovery and refinement of loci associated with lipid levels

Nature Genetics · 2013 · Vol. 45(11) · pp. 1274–1283

Cristen J. Willer✉(University of Michigan)Cristen J Willer (University of Michigan)Ellen M. Schmidt(University of Michigan)Cristen J. Willer(Broad Institute)Jennifer L. Bragg‐Gresham(Uppsala University)Sebanti Sengupta(University of Michigan) Carlo Sidore(Uppsala University)Gonçalo R. Abecasis(University of Michigan)Michael Boehnke(University of North Carolina at Chapel Hill)Cristen J Willer(Brigham and Women's Hospital)Anne Jackson(University of Michigan)Tanya M. Teslovich(University of Michigan)Ming‐Huei Chen(National Health Research Institutes)L. Adrienne Cupples(Boston University)Gina M Peloso (Broad Institute)Richa Saxena(Broad Institute)Gina M Peloso(Broad Institute) Sekar Kathiresan(Broad Institute)Ron Do(Broad Institute) Sekar Kathiresan(Broad Institute)Tōnu Esko(Broad Institute)Cameron D. Palmer(Broad Institute) Sailaja Vedantam(Broad Institute) Joel N Hirschhorn (Broad Institute)Gina M Peloso(Broad Institute)Pierre Fontanillas(Broad Institute) Erik Ingelsson(Uppsala University)Ci Song(Uppsala University)Stefan Gustafsson(Uppsala University) Agneta Siegbahn (Uppsala University)Andrea Ganna(Uppsala University) Erik Ingelsson(Uppsala University)Ci Song(Uppsala University)Stefan Gustafsson(Uppsala University)Andrea Ganna(Uppsala University)Kathleen Stirrups(Cedars-Sinai Medical Center)Manjinder S. Sandhu(University of Cambridge)Panos Deloukas(Tampere University)Cristina Pomilla(University of Cambridge)Stavroula Kanoni(King's College London) Elizabeth H Young(University of Cambridge) Theodore Papamarkou(University of Maryland, Baltimore)Inês Barroso(Wellcome Sanger Institute) Deepti Gurdasani(University Medical Center Groningen)Samuli Ripatti(University of Maryland, Baltimore)Nicholas W.J. Wainwright(Broad Institute)Patrik K. E. Magnusson(University of Helsinki)Ci Song(Uppsala University)Andrea Ganna(Uppsala University)Nancy L. Pedersen(Broad Institute)Karen L. Mohlke(University of North Carolina at Chapel Hill)Martin L. Buchkovich(University of North Carolina at Chapel Hill)Ying Wu(University of North Carolina at Chapel Hill) Daniel I Chasman(Brigham and Women's Hospital)Paul M. Ridker(Uppsala University)Samia Mora(Brigham and Women's Hospital) Daniel I Chasman(Brigham and Women's Hospital)Paul M. Ridker(Brigham and Women's Hospital)Samia Mora(Brigham and Women's Hospital)J. Beckmann(deCODE Genetics (Iceland))J. Beckmann(Erasmus MC)Hsing‐Yi Chang(National Health Research Institutes) Aaron Isaacs (Erasmus MC)Cornelia M. van Duijn(Erasmus MC)Ayşe Demirkan(Erasmus MC)Peter J. Koudstaal(University of North Carolina at Chapel Hill)Heleen M. den Hertog(Ealing Hospital)Evita G. van den Herik(Erasmus MC) Colin N A Palmer(Broad Institute)Louise A. Donnelly(Wellcome Sanger Institute)Andrew D. Morris(Ninewells Hospital)Alex S. F. Doney(Ninewells Hospital)François Mach(National Human Genome Research Institute)Georg Ehret(Johns Hopkins University)Aravinda Chakravarti(Johns Hopkins University)Georg Ehret(Johns Hopkins University)Krista Fischer(Harokopio University of Athens) Andres Metspalu(Ninewells Hospital)Tõnu Esko(Broad Institute)Evelin Mihailov(Imperial College London) Markus Perola (University of Helsinki)Evelin Mihailov(Innovation Center Iceland) Andres Metspalu(Karolinska Institutet)Tõnu Esko(Broad Institute)Mary F. Feitosa(Helmholtz Zentrum München)Ingrid B. Borecki(University of Oklahoma Health Sciences Center) Erik Ingelsson(Uppsala University)Cecilia M. Lindgren(Centre for Human Genetics) Mark I McCarthy (Centre for Human Genetics)Teresa Ferreira(Centre for Human Genetics)Igor Rudan(National Institute on Aging)Jennifer L. Bolton(Eurac Research)Sarah H. Wild(deCODE Genetics (Iceland))Jackie F. Price(Tri-Service General Hospital)James F. Wilson(Helmholtz Zentrum München)Ross M. Fraser(Cedars-Sinai Medical Center)Harry Campbell(Glasgow Centre for Population Health)Daniel F. Freitag(University of Cambridge)Cristina Pomilla(University of Cambridge)Danish Saleheen(Cedars-Sinai Medical Center) Elizabeth H Young(University of Cambridge) Theodore Papamarkou(Royal Statistical Society)Manjinder S. Sandhu(University of Cambridge)John Danesh(University of Cambridge) Deepti Gurdasani(Tampere University)Nicholas W.J. Wainwright(National Yang Ming Chiao Tung University)Kauko Heikkilä(University of Helsinki)Jaakko Kaprio(University of Helsinki)Elina Hyppönen(University Hospital of Geneva)Chris Power(University of Bristol)Aaron Isaacs (Erasmus MC)Cornelia M. van Duijn(University of Maryland, Baltimore)Ulf Gyllensten(Uppsala University)Åsa Johansson(Uppsala University)Lars Wallentin(Uppsala University)Agneta Siegbahn(Uppsala University)Åsa Johansson(Uppsala University) Patricia B Munroe(Reykjavík University)Toby Johnson(Queen Mary University of London) Patricia B Munroe(University of Helsinki)Toby Johnson(Royal Statistical Society) Marjo-Riitta Järvelin(University of Cambridge)Marika Kaakinen(Oulu University Hospital)Paul Elliott(Translational Therapeutics (United States))Marika Kaakinen(Translational Therapeutics (United States))Marjo‐Riitta Järvelin(Brigham and Women's Hospital)Jaakko Kaprio(University of Helsinki)Johannes Kettunen(University of Helsinki)Aarno Palotie(University of Helsinki) Markus Perola(University of Helsinki)Kaisa Silander(University of Helsinki) Ida Surakka(University of East Anglia)Samuli Ripatti(University of Helsinki)Johannes Kettunen(University of Helsinki) Markus Perola(University of Helsinki)Samuli Ripatti(University of Helsinki) Ida Surakka(University of Helsinki)Kaisa Silander(University of Helsinki)Marcus E. Kleber(University Medical Center Groningen) Winfried März(Broad Institute)Marcus E. Kleber(University of Mannheim)Jerome I. Rotter(Cedars-Sinai Medical Center)Xiaohui Li(Cedars-Sinai Medical Center)Eric H. Kim(Cedars-Sinai Medical Center)Ken K. Ong(MRC Unit for Lifelong Health and Ageing)Nicholas J. Wareham(Glasgow Centre for Population Health) Ruth J F Loos(University of Cambridge)Claudia Langenberg(Addenbrooke's Hospital)Jian’an Luan(University of North Carolina at Chapel Hill)Jing Hua Zhao(Addenbrooke's Hospital)Terho Lehtimäki(Tampere University)Leo-Pekka Lyytikäinen (Tampere University)Terho Lehtimäki(University of the West Indies System)Leo-Pekka Lyytikäinen (Tampere University)Tim D. Spector(Nanyang Technological University)Massimo Mangino(King's College London)Alan R. Shuldiner(University of Maryland, Baltimore)Jeffrey R. O’Connell(University of Maryland, Baltimore)May E. Montasser(University of Maryland, Baltimore)Braxton D. Mitchell(University of Maryland, Baltimore)Ann-Kristin Petersen(Helmholtz Zentrum München)Martina Müller‐Nurasyid(Johns Hopkins University)Christian Gieger(Imperial College Healthcare NHS Trust)Martina Müller‐Nurasyid(Cedars-Sinai Medical Center)Martina Müller‐Nurasyid(Helmholtz Zentrum München)Ilja M. Nolte(Loyola University Medical Center)Sailaja Vedantam(Broad Institute)Joel N. Hirschhorn(Broad Institute)Cameron D. Palmer(Broad Institute) Sailaja Vedantam (Broad Institute) Joel N Hirschhorn(Broad Institute)Cameron D. Palmer(Broad Institute) Carlo Sidore(University of Sassari)Serena Sanna(Helmholtz Zentrum München)Nelson B. Freimer(University of Helsinki)Susan K. Service(Icelandic Heart Association)Sonia Shah(Uppsala University)Mika Kivimäki(Karolinska University Hospital)Aroon D. Hingorani(National Institute on Aging)Meena Kumari(MRC Epidemiology Unit)Paul W. Franks(Broad Institute)Dmitry Shungin (Scania (Sweden))Dmitry Shungin(Scania (Sweden))Paul W. Franks(Scania (Sweden))Dmitry Shungin (Scania (Sweden))Carlo Sidore(University of Sassari)Rona J Strawbridge (Karolinska University Hospital) Anders Hamsten(Karolinska University Hospital)Rona J Strawbridge (Karolinska University Hospital) Anders Hamsten(Karolinska University Hospital)Luigi Ferrucci(Tampere University)Toshiko Tanaka(University of Helsinki)Guðmar Þorleifsson(deCODE Genetics (Iceland))Kāri Stefánsson(deCODE Genetics (Iceland))Hilma Hólm(deCODE Genetics (Iceland)) Unnur Thorsteinsdottir(deCODE Genetics (Iceland))Benjamin F. Voight(Translational Therapeutics (United States))Benjamin F. Voight(Translational Therapeutics (United States))Kelly A. Volcik(University of Eastern Finland)Eric Boerwinkle(University of Southern Denmark)Lindsay L. Waite(University of Eastern Finland)Devin Absher(University of Eastern Finland)Ken K. Ong(Uppsala University)Andrew Wong(Centre for Human Genetics)Diana Kuh(QIMR Berghofer Medical Research Institute)Weihua Zhang(Synlab Czech (Czechia)) John C Chambers(Centre for Human Genetics)John C. Chambers(University of the West Indies System)Weihua Zhang(Ealing Hospital)Jaspal S. Kooner(Imperial College Healthcare NHS Trust)Pontiano Kaleebu(Kuopio University Hospital)Rebecca N. Nsubuga(Ninewells Hospital)Gershim Asiki(Queen Mary University of London)Janet Seeley(University of East Anglia)Inês Barroso(Wellcome Sanger Institute)Inês Barroso(Wellcome Sanger Institute)Latonya Been(Eurac Research)Dharambir K. Sanghera(Glasgow Centre for Population Health)Martha L. Gravito(Group Health Cooperative)Narisu Narisu(National Human Genome Research Institute)Francis S. Collins(University of Eastern Finland)Lori L. Bonnycastle(University of Cambridge)Amy J. Swift(Finnish Institute for Health and Welfare)Paolo Brambilla(University of Oklahoma Health Sciences Center)Mary Susan Burnett(South Karelia Central Hospital)Stephen E. Epstein(Deutsches Diabetes-Zentrum e.V.)Giancarlo Cesana(Taichung Veterans General Hospital)George Dedoussis(University of Maryland, Baltimore)Maria Dimitriou(Uppsala University)Angela Döring(King's College London)Christa Meisinger(deCODE Genetics (Iceland))Angela Döring(St George's, University of London)Paul Elliott(Loyola University Medical Center) Marjo-Riitta Järvelin(University of Milan)Guðmundur I. Eyjólfsson(Universität für Weiterbildung Krems)Ulf dé Fairé(University of Eastern Finland)Bruna Gigante(Erasmus MC)Mark O. Goodarzi(Cedars-Sinai Medical Center)Michelle R. Jones(Uppsala University)Thomas Illig(Helmholtz Zentrum München)Harald Grallert(QIMR Berghofer Medical Research Institute)Norman Klopp(University Medical Center Groningen)Christopher J. Groves(Tufts University) Mark I McCarthy(Centre for Human Genetics)Göran Hallmans(Ninewells Hospital) Anneli Pouta(deCODE Genetics (Iceland))Anna-Liisa Hartikainen(Brigham and Women's Hospital)Caroline Hayward(Cedars-Sinai Medical Center)Dena Hernández(Scania (Sweden))Andrew A. Hicks(Eurac Research)Peter P. Pramstaller(Boston University)Yi-Jen Hung(Tri-Service General Hospital)Norman Klopp(Helmholtz Zentrum München)Thomas Illig(University of Michigan)G. Kees Hovingh(Wellcome Sanger Institute)John J.P. Kastelein(Broad Institute)Kay‐Tee Khaw(University of North Carolina at Chapel Hill)Pirjo Komulainen(Uppsala University)Rainer Rauramaa(University of Eastern Finland)Timo A. Lakka(University of Eastern Finland)Shih-Yi Lin(National Yang Ming Chiao Tung University)Jaana Lindström(Finnish Institute for Health and Welfare)Jaakko Tuomilehto(Universität für Weiterbildung Krems)Ruth J F Loos(Child Health and Development Institute)Ruth J. F. Loos(Child Health and Development Institute)Ruth J F Loos(Child Health and Development Institute)Wendy L. McArdle(University of Bristol)Gabrielle Müller(University Hospital Carl Gustav Carus)Ramaiah Nagaraja(National Institute on Aging)Tuomo Nieminen(Helsinki University Hospital)Tuomo V M Nieminen(Helsinki University Hospital)Tuomo V M Nieminen(Helsinki University Hospital)Ísleifur Ólafsson(Reykjavík University)Aarno Palotie(University of Helsinki)Aarno Palotie(University of Helsinki)Theodore Papamarkou(Royal Statistical Society)Anneli Pouta (Oulu University Hospital) Marjo-Riitta Järvelin(Oulu University Hospital)Daniel J. Rader(Translational Therapeutics (United States)) Muredach P Reilly(Translational Therapeutics (United States))Daniel J. Rader(Translational Therapeutics (United States)) Muredach P Reilly(Translational Therapeutics (United States)) Albert Hofman(Erasmus MC)Fernando Rivadeneira(Erasmus MC) Andre G Uitterlinden (Erasmus MC)Fernando Rivadeneira (Erasmus MC) Andre G Uitterlinden(Erasmus MC) Albert Hofman(Erasmus MC)Fernando Rivadeneira(Erasmus MC)André G. Uitterlinden(Erasmus MC)Aimo Ruokonen(University of Oulu)Nilesh J. Samani(University of Leicester)Nilesh J. Samani(University of Leicester) Winfried März(Synlab Czech (Czechia))Hubert Scharnagl(Medical University of Graz)Janet Seeley(University of East Anglia)Alena Stančáková(University of Eastern Finland)Laurence Tiret(Inserm)L. Joost van Pelt(University Medical Center Groningen)Cisca Wijmenga(University Medical Center Groningen)L. Joost van Pelt(University Medical Center Groningen)Bruce H. R. Wolffenbuttel(University Medical Center Groningen)Cisca Wijmenga(University Medical Center Groningen)Gonneke Willemsen(Amsterdam UMC Location Vrije Universiteit Amsterdam)Dorret I. Boomsma(Amsterdam UMC Location Vrije Universiteit Amsterdam)Tom Wilsgaard(UiT The Arctic University of Norway)Inger Njølstad(UiT The Arctic University of Norway)Linda S. Adair(University of North Carolina at Chapel Hill)Dominique Arveiler(Université de Strasbourg)Thomas Quertermous(Stanford University)Themistocles L. Assimes(Stanford University)Stefania Bandinelli(Azienda Sanitaria di Firenze)Franklyn I. Bennett(University of the West Indies System)Murielle Bochud(Institute of Social and Preventive Medicine)Pascal Bovet(Institute of Social and Preventive Medicine)Bernhard O Boehm(Nanyang Technological University)Bernhard O Boehm(Nanyang Technological University)Stefan R. Bornstein(University Hospital Carl Gustav Carus)Peter E. H. Schwarz(Deutsches Diabetes-Zentrum e.V.)Pascal Bovet(Institute of Social and Preventive Medicine)Michel Burnier(University of Lausanne)Jaspal S. Kooner(Imperial College Healthcare NHS Trust)John C Chambers (Imperial College Healthcare NHS Trust)Yii-Der Ida Chen(Cedars-Sinai Medical Center)Yii-Der Ida Chen(Cedars-Sinai Medical Center)Bamidele O. Tayo(Loyola University Medical Center)Stephen S. Rich(Loyola University Medical Center)Alan B. Feranil(University of San Carlos)Jean Ferrières(Hôpital Rangueil)Nelson B. Freimer(University of California, Los Angeles)Leif Groop(University of Helsinki)Leif Groop(University of Helsinki)Vilmundur Guðnason(Icelandic Heart Association)Anders Hamsten(Karolinska University Hospital)Tamara B. Harris(National Institute on Aging)Chao A. Hsiung(National Health Research Institutes)Steve E. Humphries(Cardiovascular Institute of the South)Steven C. Hunt(University of Utah)Kristian Hveem(Norwegian University of Science and Technology)Carlos Iribarren(Kaiser Permanente)Marjo‐Riitta Järvelin(Oulu University Hospital)Antti Jula(Finnish Institute for Health and Welfare)Mika Kähönen(Tampere University)Jaakko Kaprio(University of Helsinki)Antero Kesäniemi(Oulu University Hospital)Jaspal S. Kooner(Imperial College Healthcare NHS Trust)Ronald M. Krauss(OASIS Clinic)Johanna Kuusisto(University of Eastern Finland)Markku Laakso(University of Eastern Finland)Kirsten Ohm Kyvik(University of Southern Denmark)Kirsten Ohm Kyvik(University of Southern Denmark)Timo A. Lakka(University of Eastern Finland)Lars Wallentin(Uppsala University)Lars Lind(Uppsala University) Agneta Siegbahn (Uppsala University)John B. Whitfield(QIMR Berghofer Medical Research Institute)Nicholas G. Martin(QIMR Berghofer Medical Research Institute)Winfried März(Synlab Czech (Czechia))Colin A. McKenzie(University of the West Indies System)Pierre Meneton(Centre de Recherche des Cordeliers)Leena Moilanen(Kuopio University Hospital)Peter P. Pramstaller(Eurac Research)Peter P. Pramstaller(Eurac Research)Bruce M. Psaty(Group Health Cooperative)Bruce M. Psaty(Group Health Cooperative)Rainer Rauramaa(University of Eastern Finland)Danish Saleheen(University of Cambridge)Danish Saleheen(University of Cambridge)Veikko Salomaa(Finnish Institute for Health and Welfare)Jouko Saramies(South Karelia Central Hospital)Peter E. H. Schwarz(Deutsches Diabetes-Zentrum e.V.)Wayne H-H Sheu(Taichung Veterans General Hospital)Alan R. Shuldiner(University of Maryland, Baltimore) Unnur Thorsteinsdottir(deCODE Genetics (Iceland))Kāri Stefánsson(deCODE Genetics (Iceland))David P. Strachan(St George's, University of London)Elena Tremoli(University of Milan)Jaakko Tuomilehto(Universität für Weiterbildung Krems)Jaakko Tuomilehto(Universität für Weiterbildung Krems)Jaakko Tuomilehto(Universität für Weiterbildung Krems)Matti Uusitupa(University of Eastern Finland)Matti Uusitupa(University of Eastern Finland)Péter Vollenweider(University of Lausanne)Bruce H. R. Wolffenbuttel(University Medical Center Groningen)Jose M Ordovas(Tufts University)Jose M Ordovas(Tufts University)José M. Ordovás(Tufts University)Paul W. Franks(Scania (Sweden))L. Adrienne Cupples(Boston University)Stephen S. Rich(University of Virginia)Sekar Kathiresan(Broad Institute)Sekar Kathiresan(Broad Institute)

View via DOI Publisher page

Genetic Associations and Epidemiology Lipid metabolism and biosynthesis Peroxisome Proliferator-Activated ReceptorsBiologyComputational biologyGeneticsEvolutionary biology

MeSH terms

Coronary Artery DiseaseGenotypeHumansLipidsCholesterol, HDLCholesterol, LDLTriglyceridesGenetic Predisposition to DiseaseBlack PeopleWhite PeopleAsian PeopleGenome-Wide Association Study