article Open AccessTop 1% cited
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
PLoS Medicine · 2020 · Vol. 17(3) · pp. e1003062–e1003062
Tom G. Richardson✉(University of Bristol)Eleanor Sanderson(University of Bristol)Tom Palmer(University of Bristol)Mika Ala‐Korpela(Baker Heart and Diabetes Institute)Brian A. Ference(University of Cambridge)George Davey Smith✉(University of Bristol)Michael V. Holmes(University of Bristol)
Abstract
These findings suggest that apolipoprotein B is the predominant trait that accounts for the aetiological relationship of lipoprotein lipids with risk of CHD.
Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyLipid metabolism and disordersGenome-wide association studyApolipoprotein BInternal medicineLipoproteinMendelian randomizationCholesterolSingle-nucleotide polymorphismMedicineHigh-density lipoproteinApolipoprotein A1
MeSH terms
AdultAgedCoronary DiseaseFemaleHumansCholesterol, HDLCholesterol, LDLMaleMiddle AgedPhenotypeRisk FactorsTriglyceridesBiomarkersMultivariate AnalysisApolipoprotein A-I
Funding
- UK Research and Innovation
- National Institute for Health and Care Research
- British Heart Foundation
- University of Cambridge
- University of Bristol
- Cambridge University Hospitals
- Medical Research Council
- National Health and Medical Research Council
- NIHR Oxford Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre
Citations
910
FWCI
113.56
field-weighted impact
References
78
Percentile
100%
vs. same field & year
Citations per year
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