Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
Abstract
In observational epidemiology, mendelian randomisation (MR) studies provide an opportunity to study the causal association between an exposure and an outcome while reducing the risk of certain biases Little consensus exists around the reporting of MR studies, and the quality of reporting of these studies has been inconsistent; many MR study reports do not state or examine the various assumptions of MR and report insufficient details on the data sources STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation), a checklist of 20 reporting items, has been developed for the communication of MR studies This article explains the rationale of these checklist items and provides examples of transparent reporting MR study authors, reviewers, and journal editors are encouraged to use STROBE-MR to improve the reporting of these studies on 18 July
MeSH terms
Funding
- National Science Foundation
- Wellcome Trust
- Public Health Agency of Canada
- University Hospitals Bristol NHS Foundation Trust
- Compute Canada
- NIHR Bristol Biomedical Research Centre
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- European Commission
- University of Bristol
- Public Health Agency
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Jewish General Hospital
- Norges Forskningsråd
- National Institutes of Health
- Canadian Institutes of Health Research
- Medical Research Council
- Economic and Social Research Council
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