articleTop 1% cited
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Nature Genetics · 2018 · Vol. 50(5) · pp. 693–698
Marie Verbanck✉(Icahn School of Medicine at Mount Sinai)Chia‐Yen Chen(Broad Institute)Benjamin M. Neale(Broad Institute)Ron Do(Icahn School of Medicine at Mount Sinai)
Genetic Associations and EpidemiologyGenomic variations and chromosomal abnormalitiesGenetic Mapping and Diversity in Plants and AnimalsMendelian randomizationPleiotropyBiologyGeneticsTraitMendelian inheritanceOutlierEvolutionary biologyStatisticsPhenotype
MeSH terms
DiseaseHumansGenetic VariationGenetic Predisposition to DiseaseGenetic Pleiotropy
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References
Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
Statistics in Medicine · 2015 · 1,818 citations
A global reference for human genetic variation
Nature · 2015 · 19,538 citations
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
International Journal of Epidemiology · 2003 · 6,297 citations
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
International Journal of Epidemiology · 2015 · 10,342 citations
Re: “Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects”
American Journal of Epidemiology · 2015 · 1,009 citations
An atlas of genetic correlations across human diseases and traits
Nature Genetics · 2015 · 4,591 citations
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
International Journal of Epidemiology · 2016 · 1,697 citations
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