article Open AccessTop 1% cited
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
BMJ · 2018 · Vol. 362 · pp. k601–k601
Neil M Davies✉(Medical Research Council)Michael V. Holmes(University of Oxford)George Davey Smith(National Institute for Health Research)
Abstract
Mendelian randomisation is a research method that provides evidence about putative causal relations between modifiable risk factors and disease, using genetic variants as natural experiments
Genetic Associations and EpidemiologyGenomics and Rare DiseasesBRCA gene mutations in cancerChecklistMendelian inheritanceObservational studyContext (archaeology)Mendelian randomizationPsychologyMedicineCognitive psychologyGenetic variantsBiology
MeSH terms
HumansPublic HealthGenetic VariationCausalityConfounding Factors, EpidemiologicEffect Modifier, EpidemiologicOutcome Assessment, Health CareGenome-Wide Association StudyMendelian Randomization AnalysisObservational Studies as Topic
Funding
- Imperial College London
- University of Oxford
- University of Bristol
- Erasmus Universiteit Rotterdam
- Economic and Social Research Council
Citations
4,597
FWCI
135.07
field-weighted impact
References
97
Percentile
100%
vs. same field & year
Citations per year
Cited by
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
BMJ · 2021 · 1,621 citations
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
PLoS Medicine · 2020 · 910 citations
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
BMJ · 2018 · 4,597 citations
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization
JAMA · 2021 · 3,804 citations
References
Interaction revisited: the difference between two estimates
BMJ · 2003 · 3,086 citations
Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
Statistics in Medicine · 2015 · 1,818 citations
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Statistics in Medicine · 2007 · 4,904 citations
Large Sample Properties of Generalized Method of Moments Estimators
Econometrica · 1982 · 13,720 citations
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
Nature Genetics · 2003 · 2,977 citations
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Human Molecular Genetics · 2014 · 4,933 citations
Identification and Estimation of Local Average Treatment Effects
Econometrica · 1994 · 4,045 citations
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
International Journal of Epidemiology · 2003 · 6,297 citations
Related articles
Re: “Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects”
American Journal of Epidemiology · 2015 · 1,009 citations
Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects
American Journal of Epidemiology · 2015 · 1,715 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.