review Open AccessTop 1% cited
Development and Applications of CRISPR-Cas9 for Genome Engineering
Cell · 2014 · Vol. 157(6) · pp. 1262–1278
Patrick D. Hsu✉(Harvard University)Eric S. Lander(Broad Institute)Feng Zhang(Massachusetts Institute of Technology)
CRISPR and Genetic EngineeringRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyCRISPRCas9BiologyGenome engineeringGenome editingComputational biologyGenomeGeneticsGene
MeSH terms
AnimalsBacteriaEukaryotic CellsGenetic EngineeringHumansStreptococcus pyogenesGenomeGene TargetingCRISPR-Cas Systems
Funding
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
Citations
5,789
FWCI
229.63
field-weighted impact
References
105
Percentile
100%
vs. same field & year
Citations per year
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References
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
Microbiology · 2005 · 1,315 citations
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Cell stem cell · 2013 · 1,381 citations
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Nature Biotechnology · 2013 · 2,476 citations
RNA-Guided Human Genome Engineering via Cas9
Science · 2013 · 9,293 citations
DNA targeting specificity of RNA-guided Cas9 nucleases
Nature Biotechnology · 2013 · 4,831 citations
CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology · 2014 · 3,157 citations
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science · 2012 · 16,935 citations
Multiplex Genome Engineering Using CRISPR/Cas Systems
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