article Open AccessTop 1% cited
DNA targeting specificity of RNA-guided Cas9 nucleases
Nature Biotechnology · 2013 · Vol. 31(9) · pp. 827–832
Patrick D. Hsu✉(Broad Institute)David A. Scott(McGovern Institute for Brain Research)Joshua A. Weinstein(McGovern Institute for Brain Research)F. Ann Ran(McGovern Institute for Brain Research)Silvana Konermann(Broad Institute)Vineeta Agarwala(Harvard University)Yinqing Li(Massachusetts Institute of Technology)Eli J. Fine(Emory University)Xuebing Wu(Massachusetts Institute of Technology)Ophir Shalem(Massachusetts Institute of Technology)Thomas J. Cradick(Emory University)Luciano A. Marraffini(Rockefeller University)Gang Bao(Georgia Institute of Technology)Feng Zhang(Massachusetts Institute of Technology)
CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanismsGuide RNACas9CRISPRBiologyNucleaseGenome editingRNAComputational biologySubgenomic mRNAGenome
MeSH terms
Bacterial ProteinsBase SequenceDeoxyribonucleasesDNAGenetic EngineeringMolecular Sequence DataStreptococcus pyogenesTranscription FactorsBase Pair MismatchRNA, Small Untranslated
Funding
- Harvard Stem Cell Institute
Citations
4,831
FWCI
156.53
field-weighted impact
References
29
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100%
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References
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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